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From Basic Research to Drug Development for Cognitive Disorders: Exploring New Hope

As the population continues to age, cognitive disorders such as Alzheimer's disease have become a significant focus of global medical research. Despite the availability of various treatments, most can only temporarily alleviate symptoms and are not curative. Based on accumulated experience in the fields of molecular neuroscience and technology, we have discovered a series of neuroprotective herbal extracts that can enhance neurotransmission and synaptic plasticity, offering new insights into potential treatments for neurodegenerative diseases.

Basic Research

One of the core pathological features of cognitive impairment is the damage to synaptic function. Synapses are the key structures for transmitting information between neurons, and their plasticity is the basis for learning and memory. By dissecting the mechanisms of synaptic function in detail, we have identified key proteins and molecular pathways, which have provided a foundation for targeted therapy. For example, certain synaptic proteins express abnormally in neurodegenerative diseases, leading to a decline in neural transmission efficiency. Our basic research has revealed the specific molecular mechanisms of these abnormalities, providing theoretical support for subsequent drug development.

Drug Screening

After identifying potential molecular targets, we turned to the screening of traditional Chinese medicine. Traditional Chinese medicine includes many components with neuroprotective effects. Using modern technology, we conducted an initial screening of hundreds of traditional Chinese medicines and selected several herbal extracts that demonstrated promotion of neurotransmission and synaptic plasticity in experiments. These extracts not only have potential therapeutic effects but also have relatively low toxicity due to their natural origins, providing a solid foundation for further research.

Verification of function

The candidate substances identified through drug screening need to undergo functional validation in animal models to determine their efficacy and safety. Genetically modified Alzheimer's mice were chosen as experimental subjects and treated with the herbal extracts. The results showed that these extracts not only improved the mice's learning and memory abilities but also significantly reduced the deposition of beta-amyloid protein in their brains, providing strong support for their potential clinical application.

Toxicity test

In the drug development process, safety assessment is a crucial step. We conducted comprehensive toxicity tests on the selected herbal extracts, covering acute toxicity, subacute toxicity, and chronic toxicity. By verifying the complete pathological pathways, the results indicated that these extracts have good safety profiles, with no significant toxic or side effects observed.

Preclinical study

In the preclinical research phase, we utilized transcriptomics and proteomics analyses to further understand the mechanisms of action and therapeutic potential of the candidate drugs. Transcriptomics analysis helped us reveal the effects of the drugs on gene expression, identifying key genes and signaling pathways related to neuroprotection. Proteomics analysis provided a comprehensive view of the drugs' effects on protein expression and modification, helping us understand their specific actions at the cellular and molecular levels. These data provide important foundations for clinical trial design and drug optimization.

From basic research to preclinical studies, our work demonstrates how we can develop potential treatments for cognitive disorders by elucidating synaptic function mechanisms and screening and validating herbal extracts. This process not only highlights the integration of modern technology with traditional Chinese medicine but also brings new hope for the treatment of cognitive disorders. We believe that, with continued research, these herbal extracts have the potential to offer patients safer and more effective treatment options.


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